Adsorption of Histidine and Histidine-Containing Peptides on Au(111)

A series of small biomolecules were studied by adsorption in vacuum and/or from the liquid phase on gold single crystal.

Feyer et al.,  Langmuir 26 (2010) 8606-8613.

There is general interest in the organic-metal interface, and how chemical bonds are formed. In the particular case where the metal is gold, there is wide interest in the nature of chemical bonds for functionalisation of gold nanoparticles, drug delivery systems and a sensor development based on adsorption on gold. In the present work a series of small biomolecules were studied by adsorption in vacuum and/or from the liquid phase on gold single crystals. From core level photoemission and NEXAFS, information was obtained about the orientation of the chromophores of the molecules and the nature of their interaction with the surface. The imidazole ring and the carboxylic acid group bond more strongly, while the peptide, -C(O)NH- and amino groups bond less strongly with the surface.

Organic materials are well known to be sensitive to radiation damage, but the lower flux of the beamline (combined with an efficient electron energy analyser) mean that radiation damage is usually not a problem when studying biomlecules adsorbed on surfaces.

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Adsorption of Histidine and Histidine-Containing Peptides on Au(111),V. Feyer, O. Plekan, N. Tsud, V. Cháb, V. Matolín, K.C. Prince, Langmuir 26 (2010) 8606-8613.
10.1021/la904684e
Last Updated on Sunday, 24 April 2016 19:42