Towards synchrotron phase-contrast lung imaging in patients


   W.L. Wagner et al., "Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom", J. Synchrotron Rad. 25, 1 (2018). https://doi.org/10.1107/S1600577518013401

 

In-line free propagation phase-contrast synchrotron tomography of the lungs
has been shown to provide superior image quality compared with attenuation based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a chest phantom with ventilated fresh porcine lungs. Local areas of interest were imaged with a pixel size of 100 mm, yielding a high-resolution depiction of anatomical hallmarks of healthy lungs and artificial lung nodules. Details like fine spiculations into surrounding alveolar spaces were shown on a micrometre scale. Minor differences in artificial lung nodule density were detected by phase retrieval. Since we only applied a fraction of the X-ray dose used for clinical high-resolution CT scans, it is believed that this approach may become applicable to the detailed assessment of focal lung lesions in patients in the future.

 


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W. L. Wagner, F. Wuennemann, S. Pacilé, J. Albers, F. Arfelli, D. Dreossi, J. Biederer P. Konietzke, W. Stiller, M.O. Wielpütz, A. Accardo, M. Confalonieri, M. Cova, J. Lotz, F. Alves, H.-U. Kauczor, G. Tromba and C. Dullin, "Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom", J. Synchrotron Rad. 25, 1 (2018). https://doi.org/10.1107/S1600577518013401

 
Last Updated on Friday, 18 October 2019 10:10