Dr. Babu A. MANJASETTY

Babu A. Manjasetty is involved in conducting many research investigations in the areas of Structural Biology and Synchrotron Based Macromolecular Crystallography which have led to 50+ research publications in high impact journals and books.

Editorial Board of Acta Crystallographica Section F., International Union of Crystallography (IUCr) Journal

MOST CITED PUBLICATIONS

• Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate.
  Proceedings of National Academy of Sciences, USA., 2003:100(12): 6992–6997. (DOI: 10.1073/pnas.1236794100)
• Structure-function relationships of two paralogous single-stranded DNA-binding proteins from Streptomyces coelicolor: implication of SsbB in chromosome segregation during sporulation.
  Nucleic Acids Research, 2013:41(6):3659-3672 (DOI: 10.1093/nar/gkt050)
• Crystal structures of recombinant histones HMfA and HMfB from the hyperthermophilic archaeon Methanothermus fervidus.
  Journal of Molecular Biology, 2000:303(1):35-47 (DOI: 10.1006/jmbi.2000.4104)
• Metalloproteomics: high-throughput structural and functional annotation of proteins in structural genomics.
  Structure (London, England), 2005:13(10):1473-1486 (DOI: 10.1016/j.str.2005.07.014)
• Automated technologies and novel techniques to accelerate protein crystallography for structural genomics.
  Proteomics, 2008: 8(4):612-625(DOI: 10.1002/pmic.200700687) Review
• Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production.
  Journal of Molecular Biology, 2006:360(2):297-309 (DOI: 10.1016/j.jmb.2006.04.040)
• Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases.
  Nucleic Acids Res. 2014:42(12): 7894–7910(DOI: 10.1093/nar/gku425)
• Crystal Structure of Calcium Binding Protein-5 from Entamoeba histolytica and Its Involvement in Initiation of Phagocytosis of Human Erythrocytes.
  PLoS Pathogens 2014: 10(12): e1004532 (DOI: 10.1371/journal.ppat.1004532)

PRESENT AND PREVIOUS EMPLOYMENTS

• Elettra Synchrotron Light Source, Trieste, ITALY
  2018 to Present | IISc-ICTP Beamline Scientist [Indo-Italian 11.2C - XRD2 Beamline]
• European Molecular Biology Laboratory: Grenoble, FRANCE
  2010 to 2018 | Staff Scientist (ESRF/DBT/EMBL-BM14 Beamline]
• Centre for Synchrotron Biosciences, National Synchrotron Light Source, Upton, New York, USA
  2004 to 2009 | Beamline Scientist [Rockefeller University/AECOM/CWRU/Sloan Kattering Cancer Centre X3A/X9A Beamline]
• Berliner Elektronenspeicherring-Gesellschaft für Synchrotronstrahlung (BESSY) : Berlin, GERMANY
  2002 to 2004 | Deputy Beamline Scientist [Protein Structure Factory MX Beamlines]
• Department of Collegiate Education: Bangalore, Karnataka, INDIA;
  1994 to 1998 | Lecturer in Physics
• Prof. MRN Murthy Lab, Molecular Biophysics Unit, Indian Institute of Science: Bangalore, INDIA
  1994 to 1998 | Visiting Researcher

POST-DOCTORAL

• Prof. Alice Vrielink Lab, University of California Santa Cruz: Santa Cruz, California, USA and Biotechnology Research Institute of the National Research Council, McGill University, Montreal, CANADA
  2000 to 2002 | National Institute of Health (NIH) Research Fellow
• Prof. Dr. Udo Heinemann Lab, Max Delbrück Centrum für Molekulare Medizin Berlin Buch: Berlin, GERMANY
  1998 to 2000 | Alexander von Humboldt (AvH) Research Fellow

EDUCATION

Ph.D Physics (X-ray Crystallography), University of Mysore: INDIA;
1988 to 1994 | University Grants Commission (UGC) Research Fellow

M.Sc., Physics (Solid State Physics), University of Mysore: INDIA;
1985 to 1988 | First Class/Distinction/University Topper(2)

B.Sc., Physics, Chemistry, Mathematics, University of Mysore: INDIA;
1982 to 1985 | First Class/Distinction - National Merit Scholar (NMS)