The AntiHelix consortium includes five renowned academic laboratories with a long-standing interest in the field of DNA helicases (CNR, UCPH, USFD, ELETTRA, SLU), with a wide range of technical and scientific expertises, ranging from cell biology to biochemistry to structural biology, and working on different but interconnected DNA helicases; one world leader in the field of single molecules biophysical studies of protein-DNA interaction (VU); one research group dedicated to clinical oncology studies (UKESSEN); three companies involved in various stages of drug discovery (LDC, EDELRIS, PPSC) and one company developing state-of-the-art instrumentation for biophysical studies (LUMICKS). This web of research groups and institutions will provide a thriving and innovative scientific environment that potentially offers unique opportunities to develop a strong research programme at the interface between different disciplines (cell biology, biochemistry, structural biology, biophysics, single molecule approaches, optics, medicinal chemistry, drug design, computational biology/chemistry, clinical oncology) with complementary experimental approaches and a strong emphasis on translation of scientific results.

Beneficiaries

• Istituto di Biochimica e Biologia Cellulare del Consiglio Nazionale delle Ricerche, Naples, IT (CNR) - Coordinator
• Elettra - Sincrotrone Trieste, IT (ELETTRA)
• University of Copenhagen, DK (UCPH)
• Vrije Universiteit Amsterdam, NL (STICHTING VU)
• University of Sheffield, UK (USFD)
• University Hospital University of Duisburg-Essen, DE (UKESSEN)
• Lead Discovery Center GmbH, Dortmund, DE (LDC)
• Edelris SAS, Lyon, FR (EDELRIS)
• Lumicks BV, Amsterdam, NL (LUMICKS)

Partners

• Washington University, Saint Louis, US (WUSTL)
• SISSA Medialab, Trieste, IT (SISSA ML)
• Università degli Studi della Campania Luigi Vanvitelli, Caserta, IT (UVAN, https://www.unicampania.it/)
• Université Grenoble Alpes, Grenoble, FR (UGA, https://www.univ-grenoble-alpes.fr/)
• Università degli studi Trieste, IT (UniTS, https://web.units.it/dottorato/chimica/en/node/7638)

Project Officers: Mattia Zilli and Giuliana Donini

Coordinator: Francesca Pisani

Deputy Coordinator: Ian Hickson

Training Coordinator: Ying Liu

Website Manager and Outreach Coordinator: Silvia Onesti

Supervisory Board