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Structure of Human NAPE-PLD: Regulation of Bioactive Lipids Biosynthesis by Bile Acids

The secrets of anti-ageing. Longevity and healthy ageing are affected by our diet and lifestyle. EU-funded researchers have associated certain organic compounds called fatty acid ethanolamides (FAEs) with obesity and ageing.
Magotti P et al., Structure 23, 3 (2015)
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Human NAPE-PLD is a key membrane-bound enzyme involved in the biosynthesis of the endocannabinoid anandamide and other bioactive lipid signaling amides.
Detailed structural findings obtained on the XRD1 beamline provide the structural basis to understand how this protein senses the content of fat in nutrients to modulate essential pathophysiological processes, including appetite, aging, synaptic plasticity, stress and mood.

Retrieve Article

Structure of human NAPE-PLD: regulation of fatty-acid ethanolamide biosynthesis by bile acids;
Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G,
Structure 23, 3 (2015)
doi:10.1016/j.str.2014.12.018

Last Updated on Tuesday, 04 December 2018 15:03