Research

Recent Publications

* Corresponding author
# Shared first author

2022

Semrau, M. S.; Giachin, G.; Covaceuszach, S.; Cassetta, A.; Demitri, N.Storici, P.*; Lolli, G.* (2022) Molecular Architecture of the Glycogen- Committed PP1/PTG Holoenzyme. Nat Commun13 (1), 6199. https://doi.org/10.1038/s41467-022-33693-z.

Pelliccia, S.; Cerchia, C.; Esposito, F.; Cannalire, R.; Corona, A.; Costanzi, E.; Kuzikov, M.; Gribbon, P.; Zaliani, A.; Brindisi, M.; Storici, P.; Tramontano, E.; Summa, V.  (2022) Easy Access to α-Ketoamides as SARS-CoV-2 and MERS Mpro Inhibitors via the PADAM Oxidation Route. European Journal of Medicinal Chemistry, 114853. https://doi.org/10.1016/j.ejmech.2022.114853.

Balboni, B., Tripathi, S. K., Veronesi, M., Russo, D., Penna, I. ,Giabbai, B., Bandiera, T., Storici, P., Girotto, S.,* Cavalli, A.* (2022) Identification of Novel GSK-3β Hits Using Competitive Biophysical Assays. Int. J. Mol. Sci., 18. https://doi.org/10.3390/ijms23073856.

Demuro, S.; Sauvey, C.; Tripathi, S. K.; Di Martino, R. M. C.; Shi, D.; Ortega, J. A.; Russo, D.; Balboni, B.; Giabbai, B.Storici, P.; Girotto, S.; Abagyan, R.,* Cavalli, A.* (2022) ARN25068, a Versatile Starting Point towards Triple GSK-3β/FYN/DYRK1A Inhibitors to Tackle Tau-Related Neurological Disorders. European Journal of Medicinal Chemistry, 229, 114054. https://doi.org/10.1016/j.ejmech.2021.114054.

2021

Costanzi, E.#; Kuzikov, M., Esposito, F., Albani, S., Demitri, N., Giabbai, B., Camasta, M., Tramontano, E., Rossetti, G., Zaliani, A., Storici, P.* (2021). Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. International Journal of Molecular Sciences22 (21), 11779. https://doi.org/10.3390/ijms222111779

Brullo C., Rapetti F., Abbate S., Prosdocimi T., Torretta A., Semrau M.S., Massa M., Alfei S., Storici P., Parisini E., Bruno O.* (2021). Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors. European Journal of Medicinal Chemistry, 223, 113638. https://doi.org/10.1016/j.ejmech.2021.113638

Gossen J., Albani S., Hanke A., Joseph B. P., Bergh C., Kuzikov M., Costanzi E., Manelfi C., Storici P., Gribbon P., Beccari A. R., Talarico C., Spyrakis F., Lindahl E., Zaliani A., Carloni P., Wade R. C., Musiani F., Kokh D. B. Rossetti G.* (2021). A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics. ACS Pharmacology & Translational Science, 4(3), 1079–1095. https://doi.org/10.1021/acsptsci.0c00215

Kuzikov M., Costanzi E., Reinshagen J., Esposito F., Vangeel L., Wolf M., Ellinger B., Claussen C., Geisslinger G., Corona A., Iaconis D., Talarico C., Manelfi C., Cannalire R., Rossetti G., Gossen J., Albani S., Musiani F., Herzog K., Ye Y., Giabbai B., Demitri N., Jochmans D., Jonghe S. D., Rymenants J., Summa V., Tramontano E., Beccari A. R., Leyssen P., Storici P., Neyts J., Gribbon P., Zaliani A.* (2021). Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. ACS Pharmacology & Translational Science, 4 (3), 1096–1110. https://doi.org/10.1021/acsptsci.0c00216

Zucchiatti P., Birarda G., Cerea A., Semrau M.S., Hubarevich A.,Storici P., De Angelis F., Toma A., Vaccari L.* (2021). Binding of tyrosine kinase inhibitor to epidermal growth factor receptor: Surface-enhanced infrared absorption microscopy reveals subtle protein secondary structure variations. Nanoscale, 13(16), 7667–7677. https://doi.org/10.1039/d0nr09200b

Annunziato G., Spadini C., Franko N., Storici P., Demitri N., Pieroni M., Flisi S., Rosati L., Iannarelli M., Marchetti M., Magalhaes J., Bettati S., Mozzarelli A., Cabassi C. S., Campanini B., Costantino G.* (2021). Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant. ACS Infectious Diseases, 7(2), 281–292. https://doi.org/10.1021/acsinfecdis.0c00378

Battista T., Pascarella G., Staid D. S., Colotti G., Rosati J., Fiorillo A., Casamassa A., Vescovi A. L., Giabbai B., Semrau M.S., Fanelli S., Storici P., Squitieri F., Morea V., Ilari A.* (2021). Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells. International Journal of Molecular Sciences, 22(3), 1293. https://doi.org/10.3390/ijms22031293

Ubbiali D., Orlando M., Kovačič M., Iacobucci C., Semrau M.S., Bajc G., Fortuna S., Ilc G., Medagli B., Oloketuyi S., Storici P., Sinz A., Grandori R., de Marco A.* (2021). An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes. International Journal of Biological Macromolecules, 182, 502–511. https://doi.org/10.1016/j.ijbiomac.2021.04.032

Peleg Y., Vincentelli R., Collins B. M., Chen K.-E., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E. K., Larsen Ø., Vaněk O., Skořepa O., Jacquemin S., Poterszman A., Kjær S., Christodoulou E., Albeck S., Dym, O., Ainbinder E., Unger T., Schuetz, A., Matthes, S., Bader, M., de Marco, A., Storici P., Semrau M.S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A., Fleishman, S. J. (2021). Community-wide experimental evaluation of the pross stability-design method. Journal of Molecular Biology, 433(13), 166964. https://doi.org/10.1016/j.jmb.2021.166964

Mohammed Khalid A.A., Parisse P.*, Medagli B.Onesti S.*, Casalis L.* (2021). Atomic Force Microscopy investigation of the interactions between the MCM helicase and DNA. Materials. 14, 687.

Bottega R., Ravera S., Napolitano L.M.R., Chiappetta V., Zini N., Crescenzi B., Arniani S., Faleschini M., Cortone G., Faletra F., Medagli B., Sirchia F., Moretti M., de Lange J., Cappelli E., Mecucci C., Onesti S., Pisani F.M., Savoia A.* (2021). Mitochondrial defect in Warsaw syndrome cells genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: A comparison with Fanconi anemia. J Cell Physiol. Online ahead of print.

2020

Veggiani G., Giabbai B., Semrau M.S., Medagli B.,Riccio V., Bajc G.,Storici P., de Marco A.* (2020). Comparative analysis of fusion tags used to functionalize recombinant antibodies. Protein Expression and Purification,166, 105505. https://doi.org/10.1016/j.pep.2019.105505

Pachetti M., Marini B., Benedetti F., Giudici F., Mauro E., Storici P., Masciovecchio C., Angeletti S., Ciccozzi M., Gallo R. C., Zella D., & Ippodrino R.* (2020). Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.Journal of Translational Medicine,18(1), 179. https://doi.org/10.1186/s12967-020-02344-6

Cavalloro V., Russo K., Vasile F, Pignataro L., Torretta A., Donini S., Semrau M.S., Storici P., Rossi D., Rapetti F., Brullo C., Parisini E., Bruno O., Collina S.* (2020). Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition. Molecules, 25(4), 935. https://doi.org/10.3390/molecules25040935

De March M., Onesti S.*, De Biasio A.* (2020) Reply to: "Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?" Nat. Commun. 11, 4999.

Ullah R., Shehzad A., Ali Shah M., De March M., Ismat F., Iqbal M., Onesti S., Rahman M., McPherson M.J.* (2020). C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable From Its Disease Risk Variant (R325W). Int J Mol Sci, 21, 926.

2019

Lazzari E., El-Halawany M., De March M., Valentino F., Cantatore F., Migliore C., Onesti S., Meroni G.* (2019). Analysis of the Zn-binding domains of TRIM32, the E3 ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy 2H. Cells, 8, E254.

Bottega R., Napolitano L.M.R., Carbone A., Cappelli E., Corsolini F., Onesti S., Savoia A., Gasparini P., Faletra F.* (2019). Two further patients with Warsaw breakage syndrome. Is a mild phenotype possible? Mol. Genet. Genom. Med. 7, e693.

Gonzalez-Magaña A., Ibáñez de Opakua A., Romano-Moreno M., Murciano-Calles J., Merino N., Luque I., Rojas A.L., Onesti S., Blanco F.J., De Biasio A.* (2019). The p12 subunit of human polymerase δ uses an atypical PIP-box for molecular recognition of proliferating cell nuclear antigen (PCNA). J. Biol. Chem. 294, 3947-3956.

Soler M.A., Medagli B., Semrau M.S., Storici P., Bajc G, de Marco A, Laio A, Fortuna S.* (2019). A consensus protocol for the in silico optimisation of antibody fragments. Chem Commun 19,14043-14046. 
 
Rosa B., Marchetti M., Paredi G., Amenitsch H., Franko N., Benoni R., Giabbai B., De Marino M.G., Mozzarelli A., Ronda L., Storici P.*, Campanini B.*, Bettati S.* (2019). Combination  of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action. Int J Mol Sci.20. pii: E5219. 
 
Gobbo D., Piretti V., Di Martino R.M.C., Tripathi S.K., Giabbai B., Storici P., Demitri N., Girotto S., Decherchi S.,* Cavalli A.* (2019). Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations. J Chem Theory Comput. 15, 4646-4659. 
 
Redenti S., Marcovich I., De Vita T., Pérez C., De Zorzi R., Demitri N., Perez D.I., Bottegoni G., Bisignano P., Bissaro M., Moro S., Martinez A., Storici P., Spalluto G., Cavalli A.,* Federico S.* (2019). A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. ChemMedChem.14, 310-314.


2018

Pisani F.M.*, Napolitano E., Napolitano L.M.R., Onesti S.* (2018). Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11. Genes, 9, 564. 

De March M., Barrera-Vilarmau S., Crespan E., Mentegari E., Merino N., Gonzalez-Magaña A., Romano-Moreno M., Maga G., Crehuet R., Onesti S., Blanco F.J., De Biasio A.
* (2018). p15PAF binding to PCNA modulates the DNA sliding surface. Nucleic Acids Res. 46, 9816-9828.

Napolitano L.M.R., Marchesi A., Rodriguez A., De March M.Onesti S., Laio A.*, Torre V.* (2018). The permeation mechanism of organic cations through a CNG mimic channel. PLoS Comput. Biol. 14, e1006295. 

Caporuscio F., Tinivella A., Restelli V., Semrau M.S., Pinzi L., Storici P., Broggini M., Rastelli G. (2018). Identification of small-molecule EGFR allosteric inhibitors by high-throughput docking. Future Med. Chem. 10, 1545.

Prosdocimi T., Mollica L., Donini S., Semrau M.S., Lucarelli A.P., Aiolfi E., Cavalli A., Storici P., Alfei S., Brullo C., Bruno O., Parisini E.* (2018). Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds. Biochemistry. 57, 2876.

Stolt-Bergner P., Benda C., Bergbrede T., Besir H., Celie P.H.N., Chang C., Drechsel D., Fischer A., Geerlof A., Giabbai B., van den Heuvel J., Huber G., Knecht W., Lehner A., Lemaitre R., Nordén K., Pardee G., Racke I., Remans K., Sander A., Scholz J., Stadnik M., Storici P., Weinbruch D., Zaror I., Lua L.H.L., Suppmann S.* (2018). Baculovirus-driven protein expression in insect cells: A benchmarking study.  J. Struct Biol. 203, 71. 

Mazzolini M., Arcangeletti M., Marchesi A., Napolitano L.M.R., Grosa D., Maity S., Anselmi C., Torre V.* (2018). The gating mechanism in cyclic nucleotide-gated ion channels. Scientific Rep. 8, 45.

Carlino L., Christodoulou M.S., Restelli V., Caporuscio F., Foschi F., Semrau M.S., Costanzi E., Tinivella A., Pinzi L., Lo Presti .L, Battistutta R., Storici P., Broggini M., Passarella D., Rastelli G.* (2018). Structure-Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR. ChemMedChem. 13, 2627-2634. 
 
Raboni S., Revtovich S., Demitri N., Giabbai B., Storici P., Cocconcelli C., Faggiano S., Rosini E., Pollegioni L., Galati S., Buschini A., Morozova E., Kulikova V., Nikulin A., Gabellieri E., Cioni P., Demidkina T., Mozzarelli A.* (2018). Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity. Biochim Biophys Acta Proteins Proteom. 1866, 1260-1270.

 

2017

De March M., De Biasio A.* (2017). The dark side of the ring: role of the DNA sliding surface of PCNA.  Crit. Rev. Biochem. Mol. Biol. 52, 663.

Campaner E., Rustighi A., Zannini A., Cristiani A., Piazza S., Ciani Y., Kalid O., Golan G., Baloglu E., Shacham S., Valsasina B., Cucchi U., Pippione A.C., Lolli M.L., Giabbai B., Storici P., Carloni P., Rossetti G., Benvenuti F., Bello E., D'Incalci M., Cappuzzello E., Rosato A., Del Sal G.* (2017). Nat. Commun. 8, 15772.

Ali Shah M., Ullah R.De March M., Salahuddin Shaha M., Ismata F., Habib M., Iqbala M., Onesti S., Rahman M.* (2017). Overexpression and characterization of the 100K protein of Fowl adenovirus-4 as an antiviral target. Virus Research 238, 218-225.

Basters A., Geurink P.P., Röcker A., Witting K.F., Tadayon R., Hess S., Semrau M.S., Storici P., Ovaa H., Knobeloch K-P*, and Fritz G.* (2017). Structural basis for the specificity of USP18 towards ISG15. Nat. Struct. & Mol. Biol.24, 270-278.

Deka J.#, Mojumdar A.#, Parisse P., Onesti S.* and Casalis L.* (2017). DNA-conjugated gold nanoparticles based colorimetric assay to assess helicase activity: a novel route to screen potential helicase inhibitors. Scientific Rep. 7, 44358

De March M., Merino N., Barrera-Vilarmau S., Crehuet R., Onesti S*., Blanco F.S*. and De Biasio A.* (2017). Structural basis of human PCNA sliding on DNA. Nat. Commun. 7, 13935.

Carroni M.#De March M.#Medagli B.Krastanova I., Taylor I.A., Amenitsch H., Araki H., Pisani F.M., Patwardhan A. and Onesti S.* (2017). New insights into the GINS complex explain the controversy between existing structural models. Scientific Rep. 7, 40188.

Mojumdar A.De March M.Marino F. and Onesti S.* (2017) The human RecQ4 helicase contains a functional RQC domain that is essential for activity. J. Biol. Chem. 292, 4176-4184.

Cordeiro T.N., Chen P.C., De Biasio A., Sibille N., Blanco F.J., Hub J.S., Crehuet R. and Bernadó P.* (2017). Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly. Nucleic Acids Res. 45, 1501-1515.


2016

Ormaza G., Medagli B., Rodríguez J.A., Ibáñez de Opakua A., Merino N., Villate M., Onesti S. and Blanco F.J.* (2016). The tumor suppressor ING4 binds double stranded DNA with micromolar affinity through its disordered central region. FEBS Letters. 591, 425-432.

Kenig S.*, Faoro V., Bourkoula E., Podergajs N., Ius T., Vindigni M., Skrap M., Lah T., Cesselli D., Storici P., Vindigni A. (2016). Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs. Cancer Cell Int.16, 58.

Medagli B., Di Crescenzio P., De March M. and Onesti S.* (2016). Structure and activity of the Cdc45-Mcm2-7-GINS (CMG) complex, the replication helicase. (Chapter in "The initiation of DNA replication in eukaryotes", Ed. D. Kaplan, Springer).

Marino F.#, Mojumdar A.#, Zucchelli C. Bhardwaj A., Buratti E., Vindigni A., Musco G. and Onesti S.* (2016). Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases. Scientific Rep. 6, 21501.
 

2015

Iseppon F., Napolitano L.M.R., Torre V. and Cojoc D.* (2015). Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin 3-A. Front. Cell. Neurosc. 9, 333.

Kenig S.*, Bedolla D.E., Birarda G., Faoro V., Mitri E., Vindigni A.Storici P. and Vaccari L. (2015). Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation. Biophys Chem. 207, 90-96.

Ronda L., Bruno S., Bettati S., Storici P., Mozzarelli A.* (2015)  From protein structure to function via single crystal optical spectroscopy. Front Mol Biosci 28, 2-12. 

Gianoncelli A., Vaccari L.*, Kourousias G., Cassese D., Bedolla D.E., Kenig S.Storici P., Lazzarino M., Kiskinova M. (2015) Soft X-Ray Microscopy Radiation Damage ON Fixed Cells Investigated with Synchrotron Radiation FTIR Microscopy. Scientific Rep. 5,10250. 

Napolitano L.M.R., Bisha I., De March M., Marchesi A., Arcangeletti M., Demitri N., Mazzolini M., Rodriguez A., Magistrato A., Onesti S.*, Laio A.* and Torre V.* (2015). A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Proc. Natl. Acad. Sci. USA. 112, E3619-E3628. 

De March M., Brancatelli G., Demitri N., De Zorzi R., Hickey N., Geremia S.* (2015). A general exit strategy of monoheme cytochromes c and c2 in electron transfer complexes? IUBMB Life 67, 694-700

Lausi A.*, Polentarutti M., Onesti S., Plaisier J.R., Busetto E., Bais G., Barba L., Cassetta A., Campi G., Lamba D., Pifferi A., Mande S.C., Sarma D.D., Sharma S.M., Paolucci G. (2015). Status of the crystallography beamlines at Elettra. Eur. Phys. J. Plus 130, 43-51.

De Biasio A.*, de Opakua A.I., Mortuza G.B., Molina R., Cordeiro T.N., Castillo F., Villate M., Merino N., Delgado S., Gil-Cartón D., Luque I., Diercks T., Bernadó P., Montoya G., Blanco F.J. (2015). Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 6:7439. 

Pike A.C., Gomathinayagam S., Swuec P., Berti M., Zhang Y., Schnecke C., Marino F., von Delft F., Renault L., Costa A., Gileadi O., Vindigni A.* (2015). Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures. Proc. Natl. Acad. Sci. USA. 112, 4286-4291.

Cersosimo U., Sgorbissa A., Foti C., Drioli S., Angelica R., Tomasella A., Picco R., Semrau M.Storici  P., Benedetti F., Berti F.*, Brancolini C.* (2015)  Synthesis, Characterization and Optimization for in Vivo Delivery of a Non-Selective Isopeptidase Inhibitor as New Anti-Neoplastic Agent.  J.Med.Chem. 26;58(4):1691-704.

De March M., Di Rocco G., Hickey N., Geremia S.* (2015). High-resolution crystal structure of the recombinant diheme cytochrome c from Shewanella baltica (OS155). J Biomol. Struct. Dyn. 33, 395-403.


2014

De Biasio A., Ibáñez de Opakua A., Cordeiro T.N., Villate M., Merino N., Sibille N., Lelli M., Diercks T., Bernadó P., Blanco F.J.* (2014). p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins. Biophys J. 106, 865-874.

De March M., Demitri N., De Zorzi R., Casini A., Gabbiani C., Guerri A., Messori L., Geremia S.* (2014). Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. J Inorg Biochem. 135, 58-67.

Bedolla D., Kenig S., Mitri E., Storici P., Vaccari L.* (2014) Further insights into G1 and G0 phases of cell cycle revealed by FTIR microspectroscopy. Vib. Spec. 75: 127-135. DOI: 10.1016/j.vibspec.2014.08.007 .

Wiedemann C., Ohlenschläger O., Medagli B.Onesti S. and Görlach M.* (2014). 1H,  15N and 13C chemical shift assignments for the winged helix domains of two archeal MCM C-termini. Biomol NMR Assign. 8, 357-360. 

Mitri E., Birarda G., Vaccari L., Kenig S., Tormen M., Grenci G.* (2014). SU-8 bonding protocol for the fabrication of microfluidic devices dedicated to FTIR microspectroscopy of live cells. Lab Chip138, 4015-4021.


2013

Bedolla D.E., Kenig S., Mitri E., Ferraris P., Marcello A., Grenci G., Vaccari L.* (2013). Determination of cell cycle phases in live B16 melanoma cells using IRMS. Analyst. 138, 4015-4021

Marino F.Vindigni A. and Onesti S.* (2013). Bioinformatic analysis of RecQ4 helicases reveals the presence of a RQC domain and a Zn knuckleBiophys Chem. 177-178, 34-39

Medagli B. and Onesti S.* (2013). Structure and mechanism of hexameric helicases. Adv. Exp. Med. Biol. 767, 75-95 (Chapter in "DNA helicases and DNA motor proteins", Ed. M. Spies, Springer).

Berti M., Chaudhuri A.R., Thangavel S., Gomathinayagam S., Kenig S., Vujanovic M., Odreman F., Glatter T., Graziano S., Mendoza-Maldonado R., Marino F., Lucic B., Biasin V., Gstaiger M., Aebersold R., Sidorova J.M., Monnat R.J. Jr, Lopes M. and Vindigni A.* (2013). Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol. 20, 347-354.

Onesti S. and MacNeill S.A.* (2013) Structure and evolutionary origins of the CMG complex. Chromosoma. 122, 47-53.


2012

Parisse, P., Vindigni, A., Scoles, G. and Casalis, L.* (2012). In vitro enzyme comparative kinetics: unwinding of surface-bound DNA nanostructures by RecQ and RecQ1. J. Phys. Chem. Letters, 3, 3532-3537.

Krastanova I., Sannino V., Amenitsch H., Gileadi O., Pisani F.M. and Onesti S.* (2012). Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. J. Biol. Chem. 287, 4121-4128.

De March, M., Demitri, N., Geremia, S., Hickey, N. and Randaccio, L.* (2012). Trans and cis influences and effects in cobalamins and in their simple models. J. inorg. biochem. 116, 215-227.


2011

Mendoza-Maldonado, R., Faoro, V., Bajpai, S., Berti, M., Odreman, F., Vindigni, M., Ius, T., Ghasemian, A., Bonin, S., Skrap, M., Stanta, G. and Vindigni, A.* (2011). The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation. Mol. Cancer 10, 83.


2010

Vindigni, A., Marino, F. and Gileadi, O.* (2010). Probing the structural basis of RecQ helicase function. Biophys. Chem. 149, 67-77.

Bindi S., Fancelli D., Alli C., Berta D., Bertrand J.A., Cameron A.D., Cappella P., Carpinelli P., Cervi G., Croci V., D'Anello M., Forte B., Giorgini M.L., Marsiglio A., Moll J., Pesenti E., Pittalà V., Pulici M., Riccardi-Sirtori F., Roletto F., Soncini C., Storici P., Varasi M., Volpi D., Zugnoni P. and Vianello P.* (2010). Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity. Bioorg Med Chem. 18, 7113-7120.

Beria I., Ballinari D., Bertrand J.A., Borghi D., Bossi R.T., Brasca M.G., Cappella P., Caruso M., Ceccarelli W., Ciavolella A., Cristiani C., Croci V., De Ponti A., Fachin G., Ferguson R.D., Lansen J., Moll J.K., Pesenti E., Posteri H., Perego R., Rocchetti M., Storici P., Volpi D. and Valsasina B.* (2010). Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors. J Med Chem. 53, 3532-3551.


2009

Pike, A., Shrestha, B., Popuri, V., Burgess-Brown, N., Muzzolini, L., Costantini, S., Vindigni, A. and Gileadi, O.* (2009). Structure of the human RECQ1 helicase: identification of a putative strand-separation pin. Proc. Natl. Acad. Sci. USA 106, 1039-1044.

Costa A. and Onesti S.* (2009). Structural biology of MCM helicases. Crit. Rev. Biochem. Mol. Biol. 44, 326-342.

BaeB.,  Chen Y.-H., Costa A., Onesti S., Brunzelle J.S., Lin Y., Cann I.K.O.and Nair S.K.* (2009) Crystal Structure of an Archaeal MCM Homolog Provides Insights into the Architecture of the Replicative Helicase. Structure 17, 211-222.

Jenkinson, E.R., Costa A., Leech, A.P., Patwardhan A., Onesti S. and Chong, J.P* (2009). Mutations in sub-domain B of the MCM helicase affect DNA binding and modulate conformational transitions. J. Biol. Chem. 284, 5654-5661.
 

Ultima modifica il Lunedì, 09 Gennaio 2023 16:05