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Nanostructured liquid crystalline particles as delivery vectors for anticancer drug

Nanostructures liquid crystalline particles as delivery vectors for isofuranodiene: Characterization and in-vitro anticancer activity

Isofuranodiene is an oxygenated sesquiterpene containing a furan ring isolated from the essential oil of Smyrnium olusatrum L. (Apiaceae) owning notable anticancer activity. Despite its biological potential, the high lipophilicity along with a relatively low stability due to Cope rearrangement giving rise to a less active compound, make the perspective of its therapeutical use unlikely. Small-angle X-ray scattering, dynamic light scattering, and synchrotron-based UV resonance Raman spectroscopy were used to characterize bulk and dispersed non lamellar liquid crystalline phases as effective delivery vectors for isofuranodiene in an integrated experimental approach.
Encapsulation of isofuranodiene in the lipid matrix resulted in a transition from a cubic Im3m to a reversed hexagonal phase because of the highly lipophilic character of the drug, as obtained in SAXS easurements, and in significant shifts in the components of the Raman spectrum of isofuranodiene. The anticancer activity of isofuranodiene-loaded lipidic nanoparticles was assessed on MDA-MB 231 cell line by MTT assay and was found to be higher than that of pristine isofuranodiene.
 

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Pisani et al.Colloids and Surfaces B: Biointerfaces, Vol. 192, pp. 111050 (2020) 
Last Updated on Tuesday, 21 July 2020 10:16