XRD1 Highlights


Structure of Human NAPE-PLD: Regulation of Bioactive Lipids Biosynthesis by Bile Acids


NAPE-PLD (N-acyl phosphatidylethanolamine phospholipase D) is a key membrane-bound enzyme involved in the biosynthesis of endocannabinoids and other bioactive lipid signaling amides.
Highly detailed structural findings, obtained on XRD1, provide the structural basisto understand how this protein is tightly connected to mammal’s neurotransmission and a variety of pathophysiological processes, including gastrointestinal motility, synaptic plasticity, appetite and mood.

Retieve Article


Structure of human NAPE-PLD: regulation of fatty-acid ethanolamide biosynthesis by bile acids; Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G, Structure 23, 3 (2015) doi:10.1016/j.str.2014.12.018





Ultima modifica il Mercoledì, 08 Settembre 2021 14:57