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Glucose metabolism

Glucose metabolism is difficult to image with cellular resolution in mammalian brain tissue, particularly with 18fluorodeoxy-D-glucose (FDG) positron emission to- mography (PET). To this end, we explored the potential of synchrotron-based low-energy X-ray fluorescence (LEXRF) to image the stable isotope of fluorine (F) in phosphorylated FDG (DG-6P). 

C. Poitry-Yamate et al.Journal of Neuroscience Research  (2012).




In our study, we used synchrotron soft X-ray imaging and X-Ray Fluorescence (XRF) microscopy to study glucose uptake in retina and brain tissues at 1 um2 spatial resolution in 3 um-thick brain slices. This study demonstrates the ability to identify glucose uptake at subcellular resolution and holds remarkable potential for imaging glucose metabolism in biological tissue.
 

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Feasibility of Direct Mapping of Cerebral Fluorodeoxy-D-Glucose Metabolism In Situ at Subcellular Resolution Using Soft X-Ray Fluorescence;
C. Poitry-Yamate, A. Gianoncelli, B. Kaulich, G. Kourousias, A.W. Magill, M. Lepore, V. Gajdosik, R. Gruetter;

Journal of Neuroscience Research 2012.
doi: 10.1002/jnr.23171

Last Updated on Tuesday, 22 December 2015 15:50