XRD2 Publications

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A list of publications in which data was collected at the XRD2 beamline. All these publications can be found (and added) in the publications area in the Virtual Unified Office (VUO) web page, after registration.

Every year, ELETTRA publishes 'ELETTRA Highlights' reporting a selection of the work done at the Laboratory during the last twelve months. In this page you will find a brief presentation of the experiments done at the XRD2 beamline and present in ELETTRA Highlights, along with other relevant results obtained at the beamline.

You can access XRD2 structures released on Protein Data Bank from our BioSync page or this link.

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2025

  1. A physicochemical rationale for the varied catalytic efficiency in RNase J paralogues
    Singh Ankur Kumar, Chinnasamy Kalaiarasi, Pahelkar Nikhil Ramachandra, Gopal Balasubramanian
    Journal of Biological Chemistry, Vol. 301 - 2, p. 108152 (2025)
    doi: 10.1016/j.jbc.2024.108152 (Journal Article)
  2. Amino Acid-Mediated Enantioselective Synthesis of a Bicyclic Ketocarbaldehyde: Theoretical and Experimental Insights into a Key Intermediate for Some Polycyclic Diterpene Synthesis
    Leonelli Francesca, Vetica Fabrizio, Bodo Enrico, Russo Stefano, Michelini Lorenzo, Sturabotti Elisa, Mazzoccanti Giulia, Ciogli Alessia, Demitri Nicola, Lamba Doriano, Masi Annalisa, Migneco Luisa Maria, Bettolo Rinaldo Marini
    European Journal of Organic Chemistry, Vol. 28 - 9, p. e202401291 (2025)
    doi: 10.1002/ejoc.202401291 (Journal Article)
  3. Chiral Switch of Gadopiclenol: New Standards in MRI Probes
    Napolitano Roberta, Guidolin Nicol, Boccalon Mariangela, Fringuello Mingo Alberto, Colombo Serra Sonia, Buonsanti Federica, Fretta Roberta, Demitri Nicola, Bényei Attila, Botta Mauro, Giovenzana Giovanni Battista, Tedoldi Fabio, Baranyai Zsolt
    Advanced Science, Vol. 12 - 14, p. 2415321 (2025)
    doi: 10.1002/advs.202415321 (Journal Article)
  4. Conclusive Insight into the Coordination Complexes of a Flexible Bis(β-diketonato) Ligand and Their Phase-Dependent Structure: A Multi-Technique Approach
    Imperato Manuel, Nicolini Alessio, Mironova Olga, Benassi Enrico, Demitri Nicola, Gigli Lara, Mucci Adele, Cornia Andrea
    Chemistry – A European Journal, Vol. 31 - 32, p. e202500697 (2025)
    doi: 10.1002/chem.202500697 (Journal Article)
  5. Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity
    Iacobucci Ilaria, Cipollone Irene, Cozzolino Flora, Iaconis Daniela, Talarico Carmine, Coppola Gabriele, Morasso Stefano, Costanzi Elisa, Malune Paolo, Storici Paola, Tramontano Enzo, Esposito Francesca, Monti Maria
    International Journal of Biological Macromolecules, Vol. 295, p. 139590 (2025)
    doi: 10.1016/j.ijbiomac.2025.139590 (Journal Article)
  6. Cytotoxicity and Binding to DNA, Lysozyme, Ribonuclease A, and Human Serum Albumin of the Diiodido Analog of Picoplatin
    Ferraro Giarita, Pracharova Jitka, Gotte Giovanni, Massai Lara, Berecka Michal, Starha Pavel, Messori Luigi, Merlino Antonello
    Inorg. Chem., Vol. 64 - 18, pp. 8895-8905 (2025)
    doi: 10.1021/acs.inorgchem.4c05424 (Journal Article)
  7. Full-length inhibitor protein is the most effective to perturb human dUTPase activity
    Kőhegyi Bianka, Tóth Zoé S., Gál Enikő, Laczkovich Máté, Benedek András, Vértessy Beáta G., Nyíri Kinga
    Scientific Reports, Vol. 15 - 1, p. 4836 (2025)
    doi: 10.1038/s41598-025-86131-7 (Journal Article)
  8. Higher-order multicomponent crystals as a strategy to decrease the IC50 parameter: the case of praziquantel, niclosamide and acetic acid
    D’Abbrunzo Ilenia, Gigli Lara, Demitri Nicola, Sabena Chiara, Nervi Carlo, Chierotti Michele R., Bertoni Serena, Škorić Irena, Häberli Cécile, Keiser Jennifer, Hasa Dritan, Perissutti Beatrice
    Journal of Drug Delivery Science and Technology, Vol. 109, p. 106974 (2025)
    doi: 10.1016/j.jddst.2025.106974 (Journal Article)
  9. Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes
    Lorenzon Tommaso, Vescovo Maria, Maiullari Michele, Tonon Giovanni, Conceição Nuno Reis, Carabineiro Sónia A. C., Mahmoud Abdallah G., Dietl Martin C., Demitri Nicola, Orian Laura, Nogara Pablo A., Caligiuri Isabella, Rizzolio Flavio, Hashmi A. Stephen K., Visentin Fabiano, Scattolin Thomas
    RSC Adv., Vol. 15 - 18, pp. 14058-14071 (2025)
    doi: 10.1039/D5RA02119G (Journal Article)
  10. Kinetic and structural studies of gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis
    Ferraroni Marta, Angeli Andrea, Luca Viviana De, Capasso Clemente, Supuran Claudiu T.
    Journal of Structural Biology, Vol. 217 - 1, p. 108154 (2025)
    doi: 10.1016/j.jsb.2024.108154 (Journal Article)
  11. Macromolecular crystallography at Elettra: current and future perspectives
    Hegde Raghurama P., Demitri Nicola, Heroux Annie, Olivo Alessandro, Bais Giorgio, Cianci Michele, Storici Paola, Dumitrescu Dan-George, Varshney Nishant Kumar, Gopal Balasubramanian, Sarma D. D., Vaccari Lisa, Onesti Silvia, Polentarutti Maurizio
    Journal of Synchrotron Radiation, Vol. 32 - 3, pp. 757-765 (2025)
    doi: 10.1107/S1600577525001055 (Journal Article)
  12. Mechanism of deamination by mycobacterial deaminase selectively targeting mutagenic bases
    Porathoor Sini, Choudhury Asha Rani, Chakrabarti Rajarshi, Anand Ruchi
    Nucleic Acids Research, Vol. 53 - 6, p. gkaf171 (2025)
    doi: 10.1093/nar/gkaf171 (Journal Article)
  13. Molecular Basis of Pseudomonas syringae pv actinidiae Levansucrase Inhibition by a Multivalent Iminosugar
    Cicchi Costanza, Pazzagli Luigia, Paoli Paolo, Campigli Sara, Marchi Guido, Cardona Francesca, Clemente Francesca, Pavone Sara, Ferraroni Marta, Canovai Alberto, Matassini Camilla, Luti Simone
    J. Agric. Food Chem., Vol. 73 - 25, pp. 15981-15992 (2025)
    doi: 10.1021/acs.jafc.5c01947 (Journal Article)
  14. NAPE-PLD is target of thiazide diuretics
    Chiarugi Sara, Margheriti Francesco, De Lorenzi Valentina, Martino Elisa, Margheritis Eleonora Germana, Moscardini Aldo, Marotta Roberto, Chaves-Sanjuan Antonio, Del Seppia Cristina, Federighi Giuseppe, Lapi Dominga, Bandiera Tiziano, Rapposelli Simona, Scuri Rossana, Bolognesi Martino, Garau Gianpiero
    Cell Chemical Biology, Vol. 32 - 3, pp. 449-462.e5 (2025)
    doi: 10.1016/j.chembiol.2025.01.008 (Journal Article)
  15. Rational Optimization of D3R/GSK-3β Dual Target-Directed Ligands as Potential Treatment for Bipolar Disorder: Design, Synthesis, X-ray Crystallography, Molecular Dynamics Simulations, In Vitro ADME, and In Vivo Pharmacokinetic Studies
    Di Martino R.M.C., Russo D., Penna I., Demuro S., Dalle Vedove A., Spagnuolo R., Ottonello G., Bertozzi S.M., Summa M., Desantis J., Valeri A., Pruccoli L., Tripathi S.K., Tarozzi A., Storici P., Girotto S., Bertorelli R., Armirotti A., Cruciani G., Bandiera T., Cavalli A., Bottegoni G.
    European Journal of Medicinal Chemistry, Vol. 297, p. 117899 (2025)
    doi: 10.1016/j.ejmech.2025.117899 (Journal Article)
  16. Self-assembly of supramolecular double helix from a tetrapeptide and direct visualization by Scanning Tunneling Microscopy
    Rancan Marzio, Bisello Annalisa, Carlotto Silvia, Basagni Andrea, Schiesari Renato, Mondal Pradip Kumar, Formaggio Fernando, Santi Saverio
    Chemistry – A European Journal, Vol. 31 - 9, p. e202404080 (2025)
    doi: 10.1002/chem.202404080 (Journal Article)
  17. SidF, a dual substrate N5-acetyl-N5-hydroxy-L-ornithine transacetylase involved in Aspergillus fumigatus siderophore biosynthesis
    Poonsiri Thanalai, Stransky Jan, Demitri Nicola, Haas Hubertus, Cianci Michele, Benini Stefano
    Journal of Structural Biology: X, Vol. 11, p. 100119 (2025)
    doi: 10.1016/j.yjsbx.2024.100119 (Journal Article)
  18. Structural Characterization of B-DNA d(CGTGAATTCACG)2 in Complex with the Specific Minor Groove Binding Fluorescent Marker Hoechst 33342
    Sbirkova-Dimitrova H., Rusew R., Gerginov H., Heroux A., Shivachev B.L.
    Crystals, Vol. 15 - 1, 20 (2025)
    doi: 10.3390/cryst15010020 (Journal Article)
  19. Structural Studies of the Dopamine D4 Receptor Antagonist Sonepiprazole as an Inhibitor of Human Carbonic Anhydrases
    Angeli Andrea, Ferraroni Marta, Capasso Clemente, Supuran Claudiu T.
    ACS Med. Chem. Lett., Vol. 16 - 3, pp. 483-486 (2025)
    doi: 10.1021/acsmedchemlett.5c00034 (Journal Article)
  20. Structural and functional insights into the nuclear role of Parkinson’s disease-associated α-synuclein as a histone chaperone
    Jos Sneha, Kambaru Archanalakshmi, Prasad Thazhe Kootteri, Parthasarathi Shylaja, Kamariah Neelagandan, Nath Sangeeta, Padmanabhan Balasundaram, Padavattan Sivaraman
    Communications Biology, Vol. 8 - 1, 712 (2025)
    doi: 10.1038/s42003-025-08138-0 (Journal Article)
  21. Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target
    Gabriele Federica, Bogard Jala A., Palerma Marta, Ardini Matteo, Byrne Margaret E., Chen Xian-Ming, Petukhov Pavel A., Ippoliti Rodolfo, Angelucci Francesco, Williams David L.
    Biochemistry, Vol. 64 - 10, pp. 2212-2225 (2025)
    doi: 10.1021/acs.biochem.5c00059 (Journal Article)
  22. Thermal stability and phase evolution of topological nodal-line semimetal PtSn₄ using synchrotron X-ray powder diffraction
    N Satheasuweatha M., Gigli Lara, Demitri Nicola, Lue C.S., Kuo C.N., Arumugam Sonachalam, Joseph Boby
    Scripta Materialia, Vol. 261, p. 116627 (2025)
    doi: 10.1016/j.scriptamat.2025.116627 (Journal Article)
  23. X-ray crystallographic and kinetic studies of biguanide containing aryl sulfonamides as carbonic anhydrase inhibitors
    Baroni Chiara, Bozdag Murat, Renzi Gioele, De Luca Viviana, Capasso Clemente, Bazzicalupi Carla, Selleri Silvia, Ferraroni Marta, Carta Fabrizio, Supuran Claudiu T.
    RSC Med. Chem., Vol. 16 - 4, pp. 1633-1640 (2025)
    doi: 10.1039/D4MD01018C (Journal Article)
Last Updated on Friday, 24 September 2021 08:45