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Pore flexibility underlies the poor selectivity of CNG channels: a structural, functional and computational analysis

Cyclic nucleotide-gated (CNG) channels play important roles in transmitting information about vision and smell from sensory cells to the

brain, and share a high degree of similarity with K+ channels. Whereas K+ channels discriminate with high accuracy Na+ from K+, CNG channels do not discriminate among different cations. By combining electrophysiology, molecular dynamics simulations and X-ray crystallography we found that the pore region exhibits a dynamic structure and the pore diameter critically depends on the ion within.

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A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels, Napolitano LMR, Bisha I, De March M, Marchesi A, Arcangeletti M, Demitri N, Mazzolini M, Rodriguez A, Magistrato A, Onesti S, Laio A, Torre V
Proceedings of the National Academy of Sciences, Vol. 112 - 27, pp. E3619-E3628 (2015), doi: 10.1073/pnas.1503334112

Last Updated on Monday, 22 May 2023 15:31