XRD1 Highlights

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Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins

The picture presents the structural change in NLP protein upon sugar binding: crystal structures of NLP before (blue, left) and after glucosamine binding (green, right) on the background.

Lenarčič T et al. , Science, 2017, 358, pp 1431-1434
Van den Ackerveken G, Science, 2017, 358, Issue 6369, pp. 1383-1384


 NLP proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. NLP refers to “Necrosis and ethylene-inducing peptide 1–like proteins”, describing effects of these proteins in target plants, i.e. tissue cell death (necrosis) and production of the plant hormone ethylene, produced in response to environmental stress. Many NLPs are cytotoxins that facilitate microbial infection of eudicot plants (like tomato and tobacco), but not of monocots (like cereals and leek). The molecular basis of such specificity of members of the NLP family of toxins has been revealed through data collected on XRD1 beamline.
Further informations can be found at: http://www.elettra.eu/science/top-stories/an-extra-sugar-provides-protection.html

Retrieve Article

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins,
Lenarčič T, Albert I, Böhm H, Hodnik V, Pirc K, Zavec A B, Podobnik M, Pahovnik D, Žagar E, Pruitt R, Greimel P, Yamaji-Hasegawa A, Kobayashi T, Zienkiewicz A, Gömann J, Mortimer J C, Fang L, Mamode-Cassim A, Deleu M, Lins L, Oecking C, Feussner I, Mongrand S, Anderluh G, Nürnberger T
Science, 2017, 358, pp 1431-1434
DOI 10.1126/science.aar4188

How plants differ in toxin-sensitivity, Van den Ackerveken G, Science, 2017, 358, Issue 6369, pp. 1383-1384
DOI: 10.1126/science.aar4188


 


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